Previous month:
June 2016
Next month:
August 2016

Partitioning (logP or logD)—are you using/measuring the right descriptor?

UPDATED: Apr. 15, 2021 Most of us who’ve worked in chemistry know about logP. The partition coefficient makes it into Lipinski’s rule of five and most post-secondary educations. But when it comes to logP, we mean one exact chemical structure. If a compound ionizes, it’s not the same structure. And since most compounds investigated in pharmaceutical and pharmacological research contain ionizable sites, it’s not logP we should be concerned about, but logD. Read more →